Quercetin/Epoxidized soybean oil loaded Magnesium hydroxide composite particles with antimicrobial properties
Category
Sciences and Technology
Department
Chemistry
Student Status
Undergraduate
Research Advisor
Dr. Mazeyar Parvinzadeh Gashti
Document Type
Event
Location
Kansas 2
Start Date
10-4-2025 9:10 AM
End Date
10-4-2025 9:30 AM
Description
In recent years, developing novel composite particles has gained significant attention in the pharmaceutical industry. Quercetin, a flavonoid (a type of plant pigment and antioxidant), is found in various fruits, vegetables, and grains. Studies have shown that quercetin has anti-inflammatory, antioxidant, and potential immune-boosting properties. On the other hand, epoxidized soybean oil (ESO) is a chemical compound derived from soybean oil, modifiedthrough the epoxidation process. ESO is commonly used as a plasticizer in products such as paints, coatings, adhesives, and sealants. However, there have been few studies exploring the application of ESO in biomedical materials.
In this study, we loaded quercetin and ESO onto magnesium hydroxide particles and evaluated their antimicrobial properties. The chemical structure of the composite particles was confirmed through Fourier-transform infrared spectroscopy (FTIR). Additionally, we measured the UV-Vis spectra of magnesium chloride (MgCI2), quercetin, and ESO as precursors for the quercetin/ESO-loaded magnesium hydroxide composite particles. The antimicrobial activity of the composite particles was tested against Staphylococcus aureus, and Escherichia coli. The composite particles containing 1 and 2 g of quercetin demonstrated excellent antimicrobial properties against Staphylococcus aureus, with similar inhibition zones observed. However, they were ineffective against Escherichia coli. Our work is ongoing to study the effects of these particles against cancer cell lines.
Quercetin/Epoxidized soybean oil loaded Magnesium hydroxide composite particles with antimicrobial properties
Kansas 2
In recent years, developing novel composite particles has gained significant attention in the pharmaceutical industry. Quercetin, a flavonoid (a type of plant pigment and antioxidant), is found in various fruits, vegetables, and grains. Studies have shown that quercetin has anti-inflammatory, antioxidant, and potential immune-boosting properties. On the other hand, epoxidized soybean oil (ESO) is a chemical compound derived from soybean oil, modifiedthrough the epoxidation process. ESO is commonly used as a plasticizer in products such as paints, coatings, adhesives, and sealants. However, there have been few studies exploring the application of ESO in biomedical materials.
In this study, we loaded quercetin and ESO onto magnesium hydroxide particles and evaluated their antimicrobial properties. The chemical structure of the composite particles was confirmed through Fourier-transform infrared spectroscopy (FTIR). Additionally, we measured the UV-Vis spectra of magnesium chloride (MgCI2), quercetin, and ESO as precursors for the quercetin/ESO-loaded magnesium hydroxide composite particles. The antimicrobial activity of the composite particles was tested against Staphylococcus aureus, and Escherichia coli. The composite particles containing 1 and 2 g of quercetin demonstrated excellent antimicrobial properties against Staphylococcus aureus, with similar inhibition zones observed. However, they were ineffective against Escherichia coli. Our work is ongoing to study the effects of these particles against cancer cell lines.
