Date of Award

Spring 5-10-2022

Document Type


Degree Name

Master of Science (MS)



First Advisor

Santimukul Santra

Second Advisor

James McAfee

Third Advisor

Phillip Harries


Hyperbranched polymers are well known to be a promising new class of drug delivery system for biomedical application. In this research, a novel hyperbranched polyester polymer was synthesized by following melt polymerization technique utilizing our proprietary A2B monomer, triethylene glycol and diethylenetriaminepentaacetic acid (DTPA). This polymerization process was catalyzed by p-toluene sulfonic acid and was monitored by analyzing the polymer sample in regular time intervals. The final polymer was purified using the solvent precipitation method and characterized using MALDI-TOF, NMR, and GPC, DSC, TGA, FT-IR. The solvent diffusion method was used to formulate polymeric nanoparticle and doxorubicin drug will be encapsulated in one-pot. The “Click” chemistry was used to decorate the nanoparticle surface with folic acid for targeted drug delivery. The efficiency of this drug delivery system was monitored and analyzed by performing cell-based assays such as MTT assay, ROS study, migration assay, apoptosis, necrosis, comet assay, and drug release study. The non-small cell lung cancer (NSCLC) cells were used as a model cancer cell line.



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.