α -Tocopherol/sorbitol polyglycidyl ether loaded with Magnesium hydroxide composite particles with antimicrobial properties
Category
Sciences and Technology
Department
Chemistry
Student Status
Undergraduate
Research Advisor
Dr. Mazeyar Parvinzadeh Gashti
Document Type
Event
Location
Student Center Ballroom
Start Date
10-4-2025 2:00 PM
End Date
10-4-2025 4:00 PM
Description
In recent years, researchers have been exploring novel composite particles with antimicrobial properties for pharmaceutical applications. In this study, we loaded alpha-tocopherol, also known as vitamin E (1, 2, and 4 g) and sorbitol polyglycidyl ether mixtures onto magnesium hydroxide and evaluated their color coordinate values, cytotoxicity, and antimicrobial properties. The chemical structure of the composite particles was confirmed through Fourier-transform infrared spectroscopy (FTIR). Additionally, we measured the UV-Vis spectra of magnesium chloride (MgCl2), vitamin E, and sorbitol polyglycidyl ether as precursors for the vitamin E and sorbitol polyglycidyl ether-loaded magnesium hydroxide composite particles. Vitamin E showed the maximum absorbance peak below 350 nm, indicating potential UV protection properties. Color-spectrophotometer test was conducted on samples containing 1 and 2 g of vitamin E. The results showed that the L* values for the composite particles with 1 and 2 g of vitamin E were 97.5 and 96.6, respectively. The a* values for the samples containing 1 and 2 g of vitamin E were- 1 and -0.1, respectively. Therefore, no significant color difference was observed in the powders. The antimicrobial activity of the composite particle containing 4 g of vitamin E was tested against Staphylococcus aureus and Escherichia coli, with inhibition zones of 12.33 mm and 19.67 mm, respectively. We found no statistically significant change in A549 cell response to any of these compounds within the tested range, as determined by the MTT assay. However, there were some morphological and cell density changes when exposed to vitamin E, sorbitol polyglycidyl ether, and magnesium hydroxide. Specifically, the nuclear-to-cytoplasmic ratio increased (cell volume decreased), and cytoplasmic rounding with membrane irregularities occurred. The effect was least pronounced for magnesium hydroxide particles, but there was evidence of dose-dependent changes in the composites.
α -Tocopherol/sorbitol polyglycidyl ether loaded with Magnesium hydroxide composite particles with antimicrobial properties
Student Center Ballroom
In recent years, researchers have been exploring novel composite particles with antimicrobial properties for pharmaceutical applications. In this study, we loaded alpha-tocopherol, also known as vitamin E (1, 2, and 4 g) and sorbitol polyglycidyl ether mixtures onto magnesium hydroxide and evaluated their color coordinate values, cytotoxicity, and antimicrobial properties. The chemical structure of the composite particles was confirmed through Fourier-transform infrared spectroscopy (FTIR). Additionally, we measured the UV-Vis spectra of magnesium chloride (MgCl2), vitamin E, and sorbitol polyglycidyl ether as precursors for the vitamin E and sorbitol polyglycidyl ether-loaded magnesium hydroxide composite particles. Vitamin E showed the maximum absorbance peak below 350 nm, indicating potential UV protection properties. Color-spectrophotometer test was conducted on samples containing 1 and 2 g of vitamin E. The results showed that the L* values for the composite particles with 1 and 2 g of vitamin E were 97.5 and 96.6, respectively. The a* values for the samples containing 1 and 2 g of vitamin E were- 1 and -0.1, respectively. Therefore, no significant color difference was observed in the powders. The antimicrobial activity of the composite particle containing 4 g of vitamin E was tested against Staphylococcus aureus and Escherichia coli, with inhibition zones of 12.33 mm and 19.67 mm, respectively. We found no statistically significant change in A549 cell response to any of these compounds within the tested range, as determined by the MTT assay. However, there were some morphological and cell density changes when exposed to vitamin E, sorbitol polyglycidyl ether, and magnesium hydroxide. Specifically, the nuclear-to-cytoplasmic ratio increased (cell volume decreased), and cytoplasmic rounding with membrane irregularities occurred. The effect was least pronounced for magnesium hydroxide particles, but there was evidence of dose-dependent changes in the composites.
