Synthesis of Zinc Hydroxide/Biotin/Gelatin Composite Particles and Their Biological Function
Category
Sciences and Technology
Department
Biology
Student Status
Undergraduate
Research Advisor
Dr. Mazeyar Parvinzadeh Gashti
Document Type
Event
Location
Kansas 2
Start Date
10-4-2025 9:50 AM
End Date
10-4-2025 10:10 AM
Description
Composite particles have emerged as a promising multifunctional platform for cancer therapy due to their biocompatibility and targeted drug delivery. This study focuses on the synthesis and evaluation of zinc hydroxide/biotin/gelatin composite particles for the potential antimicrobial and targeted cancer treatment. Zinc hydroxide serves as an antimicrobial agent with cytotoxic properties, while biotin, also known as vitamin B7, helps with the metabolic processes of cells. On the other hand, gelatin was used as a stabilizing matrix. In this study, synthesis process involved co-precipitation of zinc hydroxide within a biotin-functionalized gelatin matrix, forming microparticles. Characterization technique included Fourier-transform infrared spectroscopy (FTIR) confirmed the chemical structure of the composite particles. In vitro cytotoxicity assays using MCF-7 (breast cancer cell lines), demonstrated the enhanced efficacy of the composite particles in the following order: zinc hydroxide/biotin < zinc hydroxide < zinc hydroxide/gelatin < Zinc Hydroxide/Biotin/Gelatin, attributed to the synergistic effects of biotin targeting and gelatin-mediated controlled release.
Our composite particles were also tested against Staphylococcus aureus and revealed an excellent antibacterial property. These findings underscore the potential of zinc hydroxide/biotin/gelatin composite particles as an innovative therapeutic platform for targeted and efficient cancer treatment, paving the way for further preclinical and clinical investigations.
Synthesis of Zinc Hydroxide/Biotin/Gelatin Composite Particles and Their Biological Function
Kansas 2
Composite particles have emerged as a promising multifunctional platform for cancer therapy due to their biocompatibility and targeted drug delivery. This study focuses on the synthesis and evaluation of zinc hydroxide/biotin/gelatin composite particles for the potential antimicrobial and targeted cancer treatment. Zinc hydroxide serves as an antimicrobial agent with cytotoxic properties, while biotin, also known as vitamin B7, helps with the metabolic processes of cells. On the other hand, gelatin was used as a stabilizing matrix. In this study, synthesis process involved co-precipitation of zinc hydroxide within a biotin-functionalized gelatin matrix, forming microparticles. Characterization technique included Fourier-transform infrared spectroscopy (FTIR) confirmed the chemical structure of the composite particles. In vitro cytotoxicity assays using MCF-7 (breast cancer cell lines), demonstrated the enhanced efficacy of the composite particles in the following order: zinc hydroxide/biotin < zinc hydroxide < zinc hydroxide/gelatin < Zinc Hydroxide/Biotin/Gelatin, attributed to the synergistic effects of biotin targeting and gelatin-mediated controlled release.
Our composite particles were also tested against Staphylococcus aureus and revealed an excellent antibacterial property. These findings underscore the potential of zinc hydroxide/biotin/gelatin composite particles as an innovative therapeutic platform for targeted and efficient cancer treatment, paving the way for further preclinical and clinical investigations.
