Date of Award
Spring 5-15-2021
Document Type
Thesis
Degree Name
Master of Science in Chemistry (MSChem)
Department
Chemistry
First Advisor
Dr. Santimukul Santra, ssantra@pittstate.edu
Second Advisor
Dr. James McAfee, jmcafee@pittstate.edu
Third Advisor
Dr. Serif Uran, suran@pittstate.edu
Abstract
Among various types of cancers, lung cancer reports highest death rate and Non-Small cell lung cancer causes highest mortality in lung cancers. This is mainly due to the scarcity of treatment options and the available treatment shows numerous adverse effects. In the recent times, nanotechnology paved a new path for the diagnosis and therapy of cancer. In this study, we worked on a novel, multifunctional nanoceria (NC) platform loaded with two unique drugs taxol and fingolimod, which acts in their own ways providing synergic therapeutic effect. We hypothesized that the usage of the polyacrylic acid (PAA) coated nanoceria (PNC) increases the therapeutic efficacy of drugs and minimize the side effects. Nanoceria itself possess excellent Redox property and anti-tumor activity. Using ‘click’ chemistry the surface carboxylic groups of nanoceria are conjugated with the folic acid, which targets the folic acid receptor overexpressing lung cancer A549 cells. We studied the cell death in a time dependent and dose dependent manner. The therapeutic effect of the nanomedicine was assessed with the help of ROS, cytotoxicity, apoptosis and migration assays.
Recommended Citation
Narayanam, Raghunath, "TARGETED COMBINATION THERAPY OF NSCLC USING TAXOL AND FINGOLIMOD LOADED NANOCERIA" (2021). Electronic Theses & Dissertations. 475.
https://digitalcommons.pittstate.edu/etd/475