Date of Award
Fall 12-15-2017
Document Type
Thesis
Degree Name
Master of Science in Chemistry (MSChem)
Department
Chemistry
First Advisor
Santimukul Santra
Second Advisor
Khamis Siam
Third Advisor
James McAfee
Fourth Advisor
Serif Uran
Abstract
An Abstract of the Thesis by
Wadha Alqahtani
In this study, we have synthesized linear polyester polymers from bio-based small molecules including sorbitol, glutaric acid and others. A propargylic acid derivative was used to make the resulting polymer “click”able. Melt polymerization technique was used for this polymerization reaction using a novel lipase enzyme catalyst, NOVO 435. This reaction was conducted between 90- 95 oC for 72 hours. The polymer samples were collected in each 24 h for detailed characterizations and polymerization reaction monitoring. The resulting polymer was purified and characterized using various spectroscopic methods such as NMR, GPC, FTIR, DSC and TGA. Next, these polymers were used for the formulation of polymeric drug delivery system using solvent diffusion method. The results analyzed by using (MTT) assays, and absorbance and fluorescence microscopy. The drug delivery experiments and cytotoxic tested and showed that nanoparticles has successfully effects towards cancer treatment, that was conducted by using in vitro prostate cancer cell model.
Keywords: nanoparticle, click chemistry, prostat cancer, cytotoxicy
Recommended Citation
Alqahtani, Wadha, "ONE-STEP SYNTHESIS AND CHARACTERIZATION OF BIODEGRADABLE ‘CLICK-ABLE’ POLYESTER POLYMER FOR BIOMEDICAL APPLICATIONS" (2017). Electronic Theses & Dissertations. 241.
https://digitalcommons.pittstate.edu/etd/241
Comments
ONE-STEP SYNTHESIS AND CHARACTERIZATION OF BIODEGRADABLE ‘CLICK-ABLE’ POLYESTER POLYMER FOR BIOMEDICAL APPLICATIONS