INFLAMMATORY GENE EXPRESSION IN WOMEN DIAGNOSED WITH POLYCYSTIC OVARIAN SYNDROME

Author

Myles K. Taylor, Pittsburg State UniversityFollow

Date of Award

Winter 12-6-2016

Document Type

Thesis

Department

Biology

First Advisor

Dr. Peter Chung

Second Advisor

Dr. Neal Schmidt

Third Advisor

Dr. Barbara McClaskey

Keywords

PCOS, Inflammation, Endocrine

Abstract

Polycystic ovarian syndrome (PCOS) is a common endocrine disorder in women of reproductive age. The pathophysiology of PCOS has conventionally thought to originate from androgen excess. However, recent evidence suggests that androgen excess is a downstream consequence to inflammatory dysregulation and subsequent metabolic abnormalities. Inflammatory mRNA gene expression of TNFa and IL-1ß in mononuclear cells isolated from women diagnosed with PCOS was explored using qPCR. Additionally, the correlations between body mass index (BMI) and fasting glucose on mRNA expression of TNFa and IL-1ß were explored. mRNA expression of both TNFa and IL-1ß were found to be significantly higher in PCOS subjects (P<0.01). BMI was found to significantly increase mRNA expression of TNFa and IL-1ß (PP<0.05).

Recommended Citation

Taylor, Myles K., "INFLAMMATORY GENE EXPRESSION IN WOMEN DIAGNOSED WITH POLYCYSTIC OVARIAN SYNDROME" (2016). Electronic Theses & Dissertations. 224.
https://digitalcommons.pittstate.edu/etd/224