Paul Worsley

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Aliphatic polyester polymers are suitable for delivering cancer therapeutics for targeted treatment. Herein, we synthesized a linear, biodegradable polyester polymer using polyethylene glycol-300, sorbitol, glutaric acid and 4-pentynoic acid as monomers. The synthesis was carried out using standard melt polymerization technique and catalyzed by Novozyme-435, an enzyme that is more environmentally friendly than traditional organic catalysts. Therapeutic agents and optical imaging dyes were encapsulated by the polymer during the formulation of water-dispersible nanoparticles via solvent diffusion method. The surface functional alkyne groups were used to conjugate folic acid using “click” chemistry for targeted delivery to tumors overexpressing folate receptors. The efficacy of this nanomedicine delivery system was gauged by targeting prostate cancer cells. The results were analyzed by cytotoxicity (MTT) assays, drug release studies, and fluorescence microscopy and the results will be summarized in this presentation.