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The purpose of this project was to determine the potential role of an electronic clinical decision support tool (ECDST) for optimizing antibiotic prescribing practices in rural clinical practice. The specific aim was to evalu­ate the usability and acceptability of an ECDST for antibiotic prescribing in pediatric patients in outpatient ru­ral health clinics. The data was collected from providers working with pediatric patients at Community Health Center of Southeast Kansas. The ECDST used in this project was found to have a high usability value and was accepted as a potential tool for clinical practice by the majority of the providers who used it.