Date of Award
8-1933
Document Type
Thesis
Degree Name
Master of Science (MS)
First Advisor
Dr. J. Ralph Wells
Keywords
Antigen-antibody reactions, Complement fixation, Corynebacterium diphtheriae
Abstract
Early in one's experience in a chemical laboratory he becomes acquainted with various tests which are commonly used for the detection of one chemical substance or another. Thus, for example one soon learns the value of iodine in the detection of starch, of Fehling's solution in the demonstration of the presence of protein, and of the Marsh test in proving the existence of Arsenic in various materials, et cetera. What these tests are to the chemist, precipitation, agglutination, complement fixation and the like, are to the immunologist.
Of the biological tests named, immunologists recognize complement fixation as the most sensitive reaction at their disposal either for the detection of the presence of specific antibody in a solution, or the demonstration of the existence of specific antigen in a given material. In utilizing this reaction for proving the presence of an antigen, it is necessary to employ it the test the antibody homologous for the suspected antigen. Conversely, in attempting to demonstrate the existence of a suspected antibody, its homologous antigen must be used in the test. [Taken from introduction]
Recommended Citation
Green, Viola Opal, "Corynebacterium diphtheriae as antigen in complement fixation" (1933). Electronic Theses & Dissertations. 606.
https://digitalcommons.pittstate.edu/etd/606
