Date of Award

Spring 12-15-2019

Document Type


Degree Name

Master of Science (MS)



First Advisor

Dr. Santimukul Santra

Second Advisor

Dr. Charles Neef

Third Advisor

Dr. McAfee

Fourth Advisor

Dr. Serif Uran


The main focus of this research was the development of a polymer-coated nanoceria (PNC) platform to be used as a drug delivery system. Water-dispersible PNC is synthesized using a water-based alkaline precipitation method. Cerium nitrate hexahydrate and poly (acrylic acid) are used for the preparation of PNC. The synthesized PNC was characterized using ZETA, and UV- Vis characterization techniques. Polyacrylic acid (PAA)-coated cerium oxide nanoparticles fabricated for the targeted combination therapy of TNBC (MDA-MB-231) and MCF-7. Using EDC/NHS chemistry, the surface carboxylic acid groups of nanoceria was designed and synthesized with ICAM-1 antibody to target ICAM-1 overexpressing TNBC. Next, doxorubicin with gadolinium as a Doxo-Gd prodrug was used as a therapeutic agent. The dialysis technique was used for the purification purpose of nanoparticles to remove unreacted particles. Doxo-Gd provided activable MR imaging and treatment of cancer. The cytotoxicity of the formulated PNC was evaluated using cell-based MTT assays. The cell viability and cell internalization assays were performed using TNBC & MCF-7 cells. The detailed synthetic protocols, characterization data, and experimental results are presented in this work.



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