Date of Award
Master of Science in Chemistry (MSChem)
An Abstract of the Thesis by
In this study, we have synthesized linear polyester polymers from bio-based small molecules including sorbitol, glutaric acid and others. A propargylic acid derivative was used to make the resulting polymer “click”able. Melt polymerization technique was used for this polymerization reaction using a novel lipase enzyme catalyst, NOVO 435. This reaction was conducted between 90- 95 oC for 72 hours. The polymer samples were collected in each 24 h for detailed characterizations and polymerization reaction monitoring. The resulting polymer was purified and characterized using various spectroscopic methods such as NMR, GPC, FTIR, DSC and TGA. Next, these polymers were used for the formulation of polymeric drug delivery system using solvent diffusion method. The results analyzed by using (MTT) assays, and absorbance and fluorescence microscopy. The drug delivery experiments and cytotoxic tested and showed that nanoparticles has successfully effects towards cancer treatment, that was conducted by using in vitro prostate cancer cell model.
Keywords: nanoparticle, click chemistry, prostat cancer, cytotoxicy
Alqahtani, Wadha, "ONE-STEP SYNTHESIS AND CHARACTERIZATION OF BIODEGRADABLE ‘CLICK-ABLE’ POLYESTER POLYMER FOR BIOMEDICAL APPLICATIONS" (2017). Electronic Thesis Collection. 241.