Date of Award

Winter 12-6-2016

Document Type

Thesis

Department

Biology

First Advisor

Dr. Peter Chung

Second Advisor

Dr. Neal Schmidt

Third Advisor

Dr. Barbara McClaskey

Abstract

Polycystic ovarian syndrome (PCOS) is a common endocrine disorder in women of reproductive age. The pathophysiology of PCOS has conventionally thought to originate from androgen excess. However, recent evidence suggests that androgen excess is a downstream consequence to inflammatory dysregulation and subsequent metabolic abnormalities. Inflammatory mRNA gene expression of TNFa and IL-1ß in mononuclear cells isolated from women diagnosed with PCOS was explored using qPCR. Additionally, the correlations between body mass index (BMI) and fasting glucose on mRNA expression of TNFa and IL-1ß were explored. mRNA expression of both TNFa and IL-1ß were found to be significantly higher in PCOS subjects (P<0.01). BMI was found to significantly increase mRNA expression of TNFa and IL-1ß (PP<0.05).

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