Date of Award
Master of Science (MS)
Male Holtzman rats injected with a toxic solution of lithium chloride (US) 30 minutes after drinking saccharin flavored water (CS) learned to avoid that taste upon subsequent encounter. Electron-convulsive shock (ECS) interpolated temporarily between the pairing of a novel taste (CS) and an induced gustatory illness (US) prevents the taste from being associated with the illness (Kral, 1971). The purpose of the present experiment was to determine if sodium phenobarbital pretreatment would protect the association of taste with illness, against the normally interfering effects of ECS in the interpolated intervention paradigm. This question was investigated with a 2 (sodium phenobarbital vs. saline) x 2 (ECS vs. sham shock) x 2 (conditioned vs. nonconditioned) x 2 (conditioning day vs. test day) analysis of variance design. Results suggest sodium phenobarbital pretreatment to be ineffective in preventing against ECS disruption of the taste-illness association. Conditioning of the taste aversion and ECS disruption occurred in both drug and non drug groups.
Reynolds, Stuart W., "Sodium Phenobarbital In Prevention of Electroconvulsive Shock - Induced Disruption of Taste - Illness Association" (1975). Electronic Thesis Collection. Paper 192.